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Updated: Jul 23, 2026

In vitro and in vivo Bioluminescence Reporter Gene Imaging of Human Embryonic Stem Cells
12:19

In vitro and in vivo Bioluminescence Reporter Gene Imaging of Human Embryonic Stem Cells

Published on: May 2, 2008

Monitoring gene therapy with reporter gene imaging

P Ray1, E Bauer, M Iyer

  • 1Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095-1770, USA.

Seminars in Nuclear Medicine
|November 17, 2001
PubMed

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...