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Updated: Jul 29, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Urinary excretion of vasoactive factors are correlated to sodium excretion
R W Jackson1, F A Treiber, G A Harshfield
1Georgia Prevention Institute, Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912-2500, USA.
Background:
The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans.
Procedure:
Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults.
Results:
Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans.
Conclusions:
The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.
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