Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Translocation +(7p+; Bq-) associated with recurrent abortion.

H Körner, H Agricola, H Bayer

    Humangenetik
    |May 26, 1975
    PubMed
    Summary

    A balanced translocation involving chromosomes 7 and 13 was identified in a woman experiencing recurrent miscarriages. This chromosomal abnormality, t(7;13), may impact reproductive outcomes and genetic counseling.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accurate population-based model for individual prediction of colon cancer recurrence.

    Acta oncologica (Stockholm, Sweden)·2021
    Same author

    Treatment strategies and overall survival for incurable metastatic colorectal cancer - A EURECCA international comparison including 21,196 patients from the Netherlands and Norway.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2020
    Same author

    Anastomotic leak after surgery for colon cancer and effect on long-term survival.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
    Same author

    Transanal total mesorectal excision for rectal cancer has been suspended in Norway.

    The British journal of surgery·2019
    Same author

    Author response to: Comments on: Norwegian moratorium on transanal total mesorectal excision.

    The British journal of surgery·2019
    Same author

    Norwegian moratorium on transanal total mesorectal excision.

    The British journal of surgery·2019

    Area of Science:

    • Human Genetics
    • Reproductive Biology
    • Cytogenetics

    Background:

    • Recurrent pregnancy loss affects a significant portion of women.
    • Chromosomal abnormalities are a known cause of recurrent miscarriages.
    • Balanced translocations can disrupt gene function and lead to reproductive issues.

    Purpose of the Study:

    • To identify the chromosomal abnormality in a patient with a history of recurrent abortions.
    • To characterize the specific balanced translocation.
    • To discuss the implications for genetic counseling.

    Main Methods:

    • Giemsa-banding karyotyping was performed to analyze the patient's chromosomes.
    • The translocation was precisely mapped to specific chromosomal regions.

    Main Results:

    • A balanced translocation, t(7;13)(7qter→7p22::13q14→13qter;13q14→13pter::7p22→7pter), was identified.
    • The abnormality involved the exchange of segments between the long arm of chromosome 13 and the short arm of chromosome 7.
    • The patient was phenotypically normal despite the translocation.

    Conclusions:

    • The identified balanced translocation t(7;13) is a potential cause of the patient's recurrent miscarriages.
    • Accurate karyotyping and interpretation are crucial for diagnosing chromosomal abnormalities.
    • Genetic counseling is essential for patients with balanced translocations to understand risks and reproductive options.

    Related Experiment Videos