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Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris
Paulo Roberto F. de Carvalho1, Maysa Furlan, Maria Claudia M. Young
1Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900, SP, Araraquara, Brazil
Phytochemistry
|November 17, 2001
Abstract:
In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH(2)Cl(2)/MeOH extract from leaves of Casearia sylvestris. The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. The structures of 1-3 were established on the basis of NMR spectroscopic experiments