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Carbohydrate mimetics-based glycosyltransferase inhibitors
1Institut de Chimie Organique et Analytique, CNRS UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans, France. philippe.compain@univ-orleans.fr
Bioorganic & Medicinal Chemistry
|November 17, 2001
Abstract:
The search for carbohydrate mimetics-based glycosyltransferase inhibitors is a dynamic field that emerged 10 years ago. This review presents a description of the different types of glycosyltransferase inhibitors containing a carbohydrate mimetic (primarily an iminosugar, a carbasugar or a C-glycoside) and data on their biological activity whenever such data are available. The purpose of this account is to foster a synergy between the two expanding research areas of glycomimetics and glycosyltransferases.