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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jul 12, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Tumor therapy with targeted atomic nanogenerators.

M R McDevitt¹, D Ma, L T Lai

¹Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Science (New York, N.Y.)

|November 17, 2001

Summary

Targeted alpha therapy using actinium-225 coupled to antibodies effectively killed various cancer cells in vitro and in vivo. This novel approach shows promise for treating diverse cancers with minimal toxicity.

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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Area of Science:

Oncology
Radiochemistry
Immunotherapy

Background:

High linear energy transfer alpha particles possess potent cell-killing capabilities.
Targeting cancer cells requires precise delivery of therapeutic agents.

Purpose of the Study:

To develop and evaluate molecular-sized generators of alpha-emitting isotope cascades for targeted cancer cell destruction.
To assess the efficacy and toxicity of these targeted alpha-emitting constructs in preclinical models.

Main Methods:

Coupling actinium-225 to internalizing monoclonal antibodies to create targeted alpha-emitting nanogenerators.
In vitro testing against leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cell lines.
In vivo studies involving administration to mice with solid prostate carcinoma or disseminated human lymphoma.

Main Results:

Demonstrated specific killing of multiple cancer cell types in vitro at low doses (becquerel levels).
Achieved significant tumor regression and prolonged survival in mice at higher doses (kilobecquerel levels).
Observed no significant toxicity in treated animals.

Conclusions:

Targeted alpha-emitting nanogenerators show high efficacy against a broad spectrum of cancers.
This approach offers a promising strategy for cancer therapy with a favorable safety profile.
Potential for widespread application in treating various malignancies.