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Related Experiment Video

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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

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Thomas McMahon: a dedication in memoriam.

R D Howe¹, R E Kronauer

¹Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. howe@deas.harvard.edu

Annual Review of Biomedical Engineering

|November 20, 2001

Summary

Thomas A. McMahon pioneered biomechanics, applying simple mathematical models and experiments to understand locomotion and scaling. His influential work spanned cardiac assist devices and orthopedic biomechanics.

Area of Science:

Biomechanics
Biomedical Engineering

Background:

Pioneering research in terrestrial locomotion, allometry, and scaling.
Significant contributions to cardiac assist devices and orthopedic biomechanics.
Utilized simple mathematical models validated by creative experimentation.

Discussion:

McMahon's interdisciplinary approach bridged engineering and biology.
His work exemplified the power of simplified models in complex scientific inquiry.
A legacy of innovation in applying physical principles to biological systems.

Key Insights:

Advanced understanding of how organisms move and scale.
Developed foundational concepts for medical device engineering.
Demonstrated effective integration of theoretical and experimental methods.

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Outlook:

Continued influence on biomechanical research and education.
Inspiration for interdisciplinary approaches in science and engineering.
Enduring impact on the fields of locomotion, scaling, and medical devices.