[The desirable insulin preparations from the viewpoint of insulin secretory dynamics]

Glucose fluxes are deteriorated in type 1 and type 2 diabetic patients. The mechanisms why hepatic glucose production, muscle and adipose tissue glucose uptake, and hepatic glucose uptake after meal intake are regulated with subcutaneous insulin administration, should be clarified. Insulin analogues, either stable long-acting insulin or rapidly absorbed regular insulin are now under developed.