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[Trans mucosal insulin delivery]
Y Yamasaki1, M Shichiri, M Nomura
1Department of Internal Medicine and Therapeutics, Osaka University, Graduate School of Medicine.
Insulin is usually administered by s.c. injection to subjects with type 1 and type 2 diabetes. For a long time, non-parenteral delivery approach, such as conjunctiva, nasal cavity, oral cavity, alveolar space, intestine, and rectum, etc has been tried and showed that some portion of administered insulin was absorbed through trans-mucosal route. Short-term glycemic control on diabetic animal and patients was reported to be succeeded by intra-nasal insulin, oral insulin, and insulin suppository. After administration of these insulin, insulin was absorbed as rapid as intra-muscular injection of insulin and thus could effectively control postprandial glycemic excursion in diabetic patients.
Insulin is usually administered by s.c. injection to subjects with type 1 and type 2 diabetes. For a long time, non-parenteral delivery approach, such as conjunctiva, nasal cavity, oral cavity, alveolar space, intestine, and rectum, etc has been tried and showed that some portion of administered insulin was absorbed through trans-mucosal route. Short-term glycemic control on diabetic animal and patients was reported to be succeeded by intra-nasal insulin, oral insulin, and insulin suppository. After administration of these insulin, insulin was absorbed as rapid as intra-muscular injection of insulin and thus could effectively control postprandial glycemic excursion in diabetic patients.