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[A clinical perspective, a frontiers of PPAR function]
Abstract:
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors(PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort in to PPARs. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic disease.
Insights
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors implicated in chronic diseases like diabetes and cancer. Research explores their physiological roles and therapeutic potential in managing these conditions.
Area of Science:
- Molecular biology
- Endocrinology
- Metabolic research
Context:
- Chronic diseases like diabetes, obesity, atherosclerosis, and cancer are leading causes of death in developed nations.
- These complex diseases result from genetic, environmental, and nutritional factors.
- Peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors, are increasingly recognized for their potential involvement in these chronic conditions.
Purpose:
- To review recent advancements in the field of PPARs.
- To emphasize the physiological functions of PPARs under different nutritional conditions.
- To explore the potential role of PPARs in the pathogenesis of major chronic diseases.
Summary:
- PPARs are nuclear receptors that play a crucial role in regulating metabolism and inflammation.
- Their activity is modulated by drugs like thiazolidinediones and fibrates, highlighting their therapeutic relevance.
- This review focuses on the latest research concerning PPARs' function during various nutritional states and their connection to chronic diseases.
Impact:
- Understanding PPARs' roles can lead to novel therapeutic strategies for chronic diseases.
- This research highlights the importance of nutritional status in modulating PPAR activity and disease risk.
- The findings contribute to the development of targeted treatments for metabolic and inflammatory disorders.