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[A clinical perspective, a frontiers of PPAR function].

M Suzawa¹, S Kato

¹Institute of Molecular and Cellular Biosciences, University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|November 20, 2001

Summary

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors implicated in chronic diseases like diabetes and cancer. Research explores their physiological roles and therapeutic potential in managing these conditions.

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Area of Science:

Molecular biology
Endocrinology
Metabolic research

Context:

Chronic diseases like diabetes, obesity, atherosclerosis, and cancer are leading causes of death in developed nations.
These complex diseases result from genetic, environmental, and nutritional factors.
Peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors, are increasingly recognized for their potential involvement in these chronic conditions.

Purpose:

To review recent advancements in the field of PPARs.
To emphasize the physiological functions of PPARs under different nutritional conditions.
To explore the potential role of PPARs in the pathogenesis of major chronic diseases.

Summary:

PPARs are nuclear receptors that play a crucial role in regulating metabolism and inflammation.

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Their activity is modulated by drugs like thiazolidinediones and fibrates, highlighting their therapeutic relevance.

This review focuses on the latest research concerning PPARs' function during various nutritional states and their connection to chronic diseases.

Impact:

Understanding PPARs' roles can lead to novel therapeutic strategies for chronic diseases.
This research highlights the importance of nutritional status in modulating PPAR activity and disease risk.
The findings contribute to the development of targeted treatments for metabolic and inflammatory disorders.