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Qualitative and quantitative analysis of new amino acid derivatives of anticonvulsant activity
E Pirianowicz-Chaber1, R Paruszewski
1Department of Drug Chemistry, The Medical University of Warsaw, Poland.
Abstract:
Qualitative and quantitative methods for analysis of three new amino-acidic anticonvulsants of low neurotoxicity: pyrazole-3,5-dicarboxylic acid benzylamine (1), pyrazine-2-carboxylic acid benzylamine (2) and (R, S) N-acetyl-2-pyrrolidone-5-carboxylic acid benzylamide (3) have been developed. Qualitative analysis included characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation and quantitative analysis involved spectrophotometric, chromatographic (HPLC) and acidimetric methods.
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