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INVEST: results of combined strategies to control blood pressure

R E Kolloch1

  • 1Gilead Medical Center, University of Münster School of Medicine, Bielefeld, Germany.

Clinical Cardiology
|November 20, 2001
PubMed

Insights

The International Verapamil SR/trandolapril Study (INVEST) found combination therapy effectively controls blood pressure in hypertension patients with coronary artery disease. This approach helps achieve target blood pressure goals, improving cardiovascular risk management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Management

Background:

  • Hypertension treatment is complex due to poorly understood blood pressure modulators and comorbidities like atherosclerosis and diabetes.
  • Uncertainty exists regarding optimal treatment strategies and intensity for managing hypertension.
  • Cardiovascular risk factors necessitate effective blood pressure control.

Purpose of the Study:

  • To evaluate the relationship between cardiovascular risk and blood pressure modulators.
  • To assess the efficacy of a specific treatment regimen in controlling blood pressure.
  • To inform treatment strategies for hypertensive patients, particularly those with coronary artery disease.

Main Methods:

  • The study involved the INternational VErapamil SR/trandolapril STudy (INVEST) trial.
  • Preliminary data analysis was conducted on treatment regimens and blood pressure control.
  • Focus on systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure.

Main Results:

  • The INVEST trial's treatment regimen demonstrated superior control of SBP, DBP, and pulse pressure compared to other studies.
  • Preliminary findings indicate high success rates in blood pressure management within the trial.
  • A significant proportion of patients achieved target blood pressure levels.

Conclusions:

  • Combination therapy appears highly effective for managing hypertension in patients with coronary artery disease (CAD).
  • Achieving contemporary blood pressure targets is feasible with the investigated treatment approach.
  • The findings support the use of combination therapy for improved cardiovascular outcomes in hypertensive CAD patients.

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