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Microsatellite allelotyping of chinese nasopharyngeal carcinomas
1Department of Biology, Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, People's Republic of China. bomaria@ust.hk
Background:
Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection.
Materials And Methods:
A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, I1q and 14q were used to study 47 specimens.
Results:
A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%).
Conclusion:
Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significanty associated with earlier staging