Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual variability in human tibia lead concentration.

A C Todd1, P J Parsons, S Tang

  • 1Mount Sinai School of Medicine, Department of Community and Preventive Medicine, New York, New York, USA.

Environmental Health Perspectives
|November 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cohort mortality study of lead-exposed workers in the USA, Finland and the UK.

Occupational and environmental medicine·2017
Same author

Confirming improved detection of gadolinium in bone using in vivo XRF.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2016
Same author

Detection and correlation of pre-operative, frozen section, and final pathology in high-risk endometrial cancer.

European journal of gynaecological oncology·2016
Same author

Measurement of erythrocyte protoporphyrin concentration by double extraction and spectrofluorometry.

Current protocols in toxicology·2012
Same author

Retrospective Analysis of Capecitabine and Radiation Therapy in the Treatment of Pancreatic Cancer.

The journal of applied research·2011
Same author

Clinical outcome and quality of life after surgery for peri-acetabular metastases.

The Journal of bone and joint surgery. British volume·2011
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

Human tibia lead concentration varies along the bone, with higher levels found on the surface compared to the core. These findings impact noninvasive lead measurement techniques.

Area of Science:

  • Biomedical Science
  • Toxicology
  • Human Anatomy

Background:

  • Lead exposure is a significant public health concern, and understanding its distribution in bone is crucial for accurate exposure assessment.
  • The tibia is a primary site for long-term lead storage in the human body.
  • Previous studies have indicated variability in bone lead concentration, but detailed proximal-distal and core-surface differences in the tibia require further investigation.

Purpose of the Study:

  • To investigate the proximal-distal variability of lead concentration in the adult human tibia.
  • To compare lead concentrations between the core and surface layers of the tibia.
  • To assess the implications of these findings for noninvasive tibia lead measurement methods.

Main Methods:

  • Adult human cadaver tibiae (n=10) were sampled at multiple proximal-distal locations.

Related Experiment Videos

  • Duplicate core and surface bone samples were analyzed for lead content.
  • Lead concentration was determined using electrothermal atomization atomic absorption spectrometry (ETAAS) with Zeeman background correction.

    • Main Results:

    • Lead concentrations in the analyzed tibiae ranged from 3.1 to 27.9 microg lead/g of dry bone.
    • Both core and surface tibia lead concentrations were lower at the proximal and distal ends compared to mid-shaft locations.
    • Surface tibia lead concentrations were consistently higher than core tibia lead concentrations, with differences of approximately 5-8 microg/g.

    Conclusions:

    • The adult human tibia exhibits higher lead concentrations in its surface layer compared to its core.
    • Lead distribution in the tibia is not uniform, with lower concentrations at the proximal and distal ends.
    • These results have significant implications for the interpretation and accuracy of noninvasive tibia lead measurement techniques, such as X-ray fluorescence.