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Related Experiment Videos

Relationship between asthma medication and antibiotic use.

J H Glauber1, A L Fuhlbrigge, J A Finkelstein

  • 1Clinical Effectiveness Program, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. glauber@tch.harvard.edu

Chest
|November 20, 2001
PubMed
Summary
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Asthma patients using more bronchodilators and anti-inflammatory medications, indicating more severe asthma, also used more antibiotics. This suggests a positive association between asthma medication needs and antibiotic prescriptions in asthmatics.

Area of Science:

  • Pulmonary Medicine
  • Infectious Disease Epidemiology

Background:

  • Asthma morbidity and antimicrobial resistance are significant public health issues.
  • Overuse of antibiotics and underuse of anti-inflammatory asthma medications are documented in general populations and asthmatics, respectively.
  • The relationship between asthma medication patterns and antibiotic use in asthmatics remains under-explored.

Purpose of the Study:

  • To investigate the association between asthma severity markers (bronchodilator and anti-inflammatory medication use) and antibiotic consumption in asthmatic patients.
  • To examine if physicians with lower rates of prescribing anti-inflammatory asthma medications exhibit higher rates of antibiotic prescribing.

Main Methods:

  • Retrospective cohort study design.
  • Evaluation of asthma medication and antibiotic use in pediatric and adult asthma patients (ages 6-55) within a health maintenance organization.

Related Experiment Videos

  • Analysis of antibiotic use stratified by bronchodilator and anti-inflammatory medication usage levels.
  • Correlation analysis between physician-level anti-inflammatory to bronchodilator ratio and antibiotic prescribing rates.

    • Main Results:

    • High bronchodilator users received significantly more antibiotics per person-year (1.72) compared to low users (1.23; p < 0.0001).
    • Long-term users of anti-inflammatory agents received more antibiotics per person-year (1.85) than those not using anti-inflammatories (0.95; p < 0.0001).
    • No significant correlation was found between physician prescribing patterns (anti-inflammatory to bronchodilator ratio) and their antibiotic prescribing rates.

    Conclusions:

    • A positive association exists between the intensity of asthma medication use and antibiotic consumption in asthma patients.
    • Further research is required to clarify the appropriate role, if any, of antibiotics in the management of asthma.