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Development of hypertensive status in NISAG rats reared by normotensive Wistar rats
G S Yakobson1, A R Antonov, A L Markel'
1Institute of Physiology, Siberian Division of the Russian Academy of Medical Science.
Bulletin of Experimental Biology and Medicine
|November 20, 2001
Abstract:
Parameters of the cardiovascular system and the content of corticosterone, thyrotrophin, thyroxin, and triiodothyronine in the plasma, and norepinephrine in the myocardium were determined in male NISAG rats (hereditary stress-induced arterial hypertension) reared by normotensive Wistar rats. Cross-rearing of hypertensive rat pups by normotensive females attenuated arterial hypertension with a tendency to normalization of the examined parameters. This confirms the possibility of modifying hypertensive phenotype by changing the conditions of the early postnatal development.