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Related Experiment Videos

Retrograde facilitation of memory by triazolam: effects on automatic processes.

M T Fillmore1, T H Kelly, C R Rush

  • 1Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA. mtfill2@pop.uky.edu

Psychopharmacology
|November 20, 2001
PubMed
Summary

Benzodiazepines like triazolam may enhance memory recall not by improving intentional retrieval, but by increasing automatic responses to memory cues.

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Area of Science:

  • Cognitive Neuroscience
  • Psychopharmacology

Background:

  • Benzodiazepines are known to affect memory retrieval.
  • Retrograde memory facilitation is a potential effect of benzodiazepines.

Purpose of the Study:

  • To investigate if benzodiazepine-induced memory facilitation stems from enhanced automatic retrieval processes.
  • To quantify the influence of automatic versus controlled retrieval under triazolam.

Main Methods:

  • Healthy adults received placebo or varying doses of triazolam.
  • Word-list study followed by word-stem completion task.
  • Process-dissociation used to differentiate automatic and controlled memory processes.

Main Results:

  • Triazolam administration increased the probability of using studied words in completion tasks.

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  • Memory retrieval showed a greater influence of automatic processes under triazolam.

    • Conclusions:

    • Benzodiazepine-induced retrograde memory facilitation may be driven by automatic retrieval.
    • This effect might be due to increased responsiveness to cues rather than improved intentional recall.