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Related Experiment Videos

NO diffusing capacity of rabbit lungs increases with ventilator-driven lung expansion.

H Heller1, K D Schuster

  • 1Department of Physiology, University of Bonn, Nussallee 11, 53115 Bonn, Germany. h.heller@uni-bonn.de

Pflugers Archiv : European Journal of Physiology
|November 20, 2001
PubMed
Summary

This study shows that the pulmonary diffusing capacity for nitric oxide (DL,NO) increases with lung expansion and intrapulmonary pressure. This suggests DL,NO accurately measures lung diffusion, unaffected by pressure-induced blood flow changes.

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Area of Science:

  • Physiology
  • Respiratory Medicine
  • Pulmonary Function Testing

Background:

  • The pulmonary diffusing capacity for nitric oxide (DL,NO) is hypothesized to reflect alveolar-capillary membrane properties.
  • Lung expansion is expected to improve DL,NO, but the effect of simultaneous intrapulmonary pressure changes remains unclear.

Purpose of the Study:

  • To investigate the dependence of DL,NO on ventilator-driven increases in alveolar volume and intrapulmonary pressure in an animal model.
  • To determine if DL,NO is influenced by pressure-induced alterations in pulmonary capillary blood flow.

Main Methods:

  • The single-breath method was used to measure DL,NO in four anesthetized rabbits.
  • Animals were ventilated using a computerized servo-system, with measurements taken at various alveolar volumes and intrapulmonary pressures.

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  • Nitric oxide (NO) in nitrogen was used as the indicator gas, with end-tidal PNO measured by respiratory mass spectrometry.

    • Main Results:

    • DL,NO demonstrated a significant increase concurrently with lung expansion (P<0.001).
    • DL,NO also increased with rising intrapulmonary pressure (P<0.001).

    Conclusions:

    • DL,NO measurements are influenced by both lung volume and intrapulmonary pressure.
    • The findings suggest that DL,NO provides a reliable measure of pulmonary diffusive properties, independent of pressure-induced impairments in pulmonary capillary blood flow.