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Prevention of chronic peritonitis caused by osmotic dysequilibrium in rats
1Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Objective And Design:
This study was done to determine whether peritonitis caused by osmotic dysequilibrium could be prevented by pretreatment.
Subjects:
Young adult rats were used after induction of peritonitis by intraperitoneal injections of large volumes of pure water to create severe osmotic dysequilibrium.
Treatment:
During the 1 or 2 weeks before induction of peritonitis, the rats were pretreated by intraperitoneal injections of small volumes of pure water or large volumes of moderately hypotonic electrolytes to produce a slight degree of osmotic dysequilibrium.
Methods:
Peritonitis was evaluated by macroscopic and microscopic study of peritoneal tissues.
Results:
The severity of peritonitis was greatly reduced by the pretreatments.
Conclusions:
This study adds the peritoneum to the list of tissues in which adaptation to an injury can be accomplished by pretreatment with the same injurious agent, albeit in a less noxious form.
