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Acute pancreatitis: does gender matter?

P G Lankisch1, C Assmus, D Lehnick

  • 1Department of Internal Medicine, Municipal Clinic of Lüneburg, Germany.

Digestive Diseases and Sciences
|November 21, 2001
PubMed
Summary

Gender does not independently predict acute pancreatitis severity. While etiological differences exist (alcohol in men, biliary in women), most severity markers showed no significant gender association.

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Area of Science:

  • Gastroenterology
  • Clinical Epidemiology

Background:

  • Gender is an established risk factor for severity in various diseases.
  • The role of gender in acute pancreatitis severity requires further investigation.

Purpose of the Study:

  • To investigate if gender is an independent risk factor for acute pancreatitis severity.

Main Methods:

  • Prospective epidemiological study of 274 patients with first-time acute pancreatitis.
  • Assessed severity using Atlanta criteria, Ranson's/Imrie's factors, APACHE II, CT scores, ICU/hospital stay, interventions, and mortality.

Main Results:

  • Men had higher rates of alcohol-induced pancreatitis; women had higher rates of biliary pancreatitis.
  • No significant association between gender and most acute pancreatitis severity parameters.

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  • Minor exceptions: women had longer hospital stays, higher Imrie scores, and more pseudocysts.

    • Conclusions:

    • Gender is not an independent risk factor for the severity or outcome of acute pancreatitis.
    • Etiological differences between genders do not translate to significant differences in overall disease severity.