Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Incretin hormones--an update.

J J Holst¹, C Orskov

¹Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark. holst@mfi.ku.dk

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum

|November 21, 2001

Summary

Incretin hormones like GLP-1 enhance insulin secretion and are impaired in type 2 diabetes. Therapeutic GLP-1 administration shows promise for normalizing blood sugar and potentially regenerating beta cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice.

Scandinavian journal of immunology·2014

Same author

Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats.

Diabetes, obesity & metabolism·2009

Same author

Targets and tactics: the relative importance of HbA, fasting and postprandial plasma glucose levels to glycaemic control in type 2 diabetes.

International journal of clinical practice·2009

Same author

Good glycaemic control: an international perspective on bridging the gap between theory and practice in type 2 diabetes.

Current medical research and opinion·2008

Same author

The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.

Diabetologia·2007

Same author

CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis.

Journal of virology·2007

Area of Science:

Endocrinology
Gastroenterology
Metabolic Diseases

Background:

Incretin hormones, including GIP and GLP-1, are released post-meal and enhance glucose-stimulated insulin secretion.
Incretin function is crucial for glucose homeostasis and is significantly impaired in type 2 diabetes mellitus.
Impairment involves reduced GLP-1 secretion and diminished GIP insulinotropic effects in T2DM patients.

Purpose of the Study:

To investigate the role of incretin hormones in glucose metabolism.
To explore the therapeutic potential of GLP-1 for type 2 diabetes treatment.

Main Methods:

Review of existing literature on incretin physiology and type 2 diabetes.
Analysis of GLP-1 administration effects in preclinical models and human studies.

Main Results:

GLP-1 administration in type 2 diabetes patients can normalize fasting and postprandial hyperglycemia.
GLP-1 demonstrates potential for stimulating beta-cell proliferation and differentiation in rodents.
GLP-1 exhibits additional benefits including glucagon inhibition, delayed gastric emptying, and appetite reduction.

Conclusions:

GLP-1 is a key incretin hormone with significant therapeutic potential for type 2 diabetes.
Targeting the incretin system, particularly with GLP-1, offers a promising avenue for managing type 2 diabetes.
Further development of GLP-1-based therapies is warranted for clinical application in type 2 diabetes.

Related Experiment Videos