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Peripheral lymphadenopathy in Nigeria.

K A Adeniji1, A S Anjorin

  • 1Department of Pathology, Faculty of Health Sciences, University of Ilorin, Kwara State, Nigeria.

African Journal of Medicine and Medical Sciences
|November 21, 2001
PubMed
Summary

Peripheral lymph node biopsies reveal tuberculosis as the leading cause of lymphadenopathy, with neoplastic lesions, including lymphomas and metastases, also being significant. This review highlights key diagnostic findings in Nigerian patients over 18 years.

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Area of Science:

  • Pathology
  • Oncology
  • Infectious Diseases

Background:

  • Peripheral lymphadenopathy is a common clinical finding with diverse etiologies.
  • Histopathological examination of lymph node biopsies is crucial for accurate diagnosis.
  • Understanding the spectrum of lymph node lesions is vital for public health in specific regions.

Purpose of the Study:

  • To review and analyze the histopathological diagnoses of peripheral lymph node biopsies over an 18-year period.
  • To determine the prevalence of neoplastic and non-neoplastic lesions.
  • To identify common causes of lymphadenopathy in the studied population.

Main Methods:

  • Retrospective review of 751 peripheral lymph node biopsies.
  • Analysis of histopathological reports from 1979 to 1996.

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  • Categorization of lesions into neoplastic and non-neoplastic types.
  • Main Results:

    • Non-neoplastic lesions accounted for 50.8% and neoplastic lesions for 49.2%.
    • Tuberculosis was the most frequent cause of lymphadenopathy (31.4%), followed by metastatic lesions (19.3%).
    • Lymphomas constituted 28.2% of neoplastic lesions, with non-Hodgkin's lymphoma being more prevalent than Hodgkin's disease.

    Conclusions:

    • Tuberculosis and metastatic cancers are major causes of peripheral lymphadenopathy in this Nigerian cohort.
    • Lymphomas represent a significant proportion of neoplastic lymph node lesions.
    • Cervical lymph nodes were the most commonly affected group, indicating the need for targeted diagnostic approaches.