Related Experiment Video
Updated: Aug 4, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Repressive adaptation in children with cancer: a replication and extension
1Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. sean.phipps@stjude.org
Children with cancer exhibit a repressive adaptive style, which appears to be a reaction to their diagnosis rather than a pre-existing trait. This coping mechanism remains stable over time.
Area of Science:
- Psychology
- Pediatric Oncology
- Health Psychology
Background:
- Previous studies indicate a higher prevalence of repressive adaptive styles in pediatric cancer patients.
- The origin of this repressive adaptation (premorbid vs. reactive) in children with cancer remains unclear.
Purpose of the Study:
- To investigate whether repressive adaptation in children with cancer is a premorbid characteristic or a reactive response to diagnosis.
- To assess the longitudinal changes in adaptive style among children with cancer.
Main Methods:
- A longitudinal study design was employed.
- Adaptive style was assessed in children with cancer at diagnosis, 6 months, and 1 year post-diagnosis.
- Comparison groups included healthy children and children with other chronic nonmalignant illnesses.
Main Results:
- Children with cancer demonstrated a higher incidence of repressive adaptive style at diagnosis compared to healthy children.
- The incidence of repressive adaptation remained consistent throughout the 1-year follow-up period.
- Children with other chronic illnesses exhibited similar levels of repressive adaptive style as the cancer group.
Conclusions:
- The findings suggest that the diagnosis of cancer prompts a shift towards repressive adaptation in children, which is sustained over time.
- Further research is warranted to explore the health implications of this adaptive style in pediatric cancer patients.
Related Concept Videos
Replicative Cell Senescence
Abnormal Proliferation
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Treatment Resistant Cancers
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

