Ammocidin, a new apoptosis inducer in ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation
R Murakami1, T Tomikawa, K Shin-ya
1Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
The Journal of Antibiotics
|November 21, 2001
Abstract:
The structure of ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. AJ9571, was elucidated to be as shown in Fig. 1 by NMR and degradation studies. Ammocidin consists of a 20-membered macrolide ring and three deoxy sugars identified as 6-deoxy-L-glucose, D-digitoxose and D-olivomycose.
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