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Cerebral venous thrombosis in Down's syndrome
1Department of Neurology, Medical Faculty, Ege University, Bornova, 35040, Izmir, Turkey. starlaci@hotmail.com
Insights
This study details the first reported case of cerebral venous thrombosis (CVT) in an adult with Down's syndrome (DS). The findings suggest CVT could be an underrecognized cause of stroke in individuals with DS.
Area of Science:
- Neurology
- Genetics
- Vascular Medicine
Background:
- Down's syndrome (DS) is a genetic condition associated with various health complications.
- Cerebral venous thrombosis (CVT) is a rare form of stroke.
- The association between DS and CVT has not been previously documented.
Observation:
- A 25-year-old adult male with Down's syndrome presented with a generalized tonic-clonic seizure.
- The patient experienced a prolonged postictal period following the seizure.
- Cerebral magnetic resonance imaging (MRI) and MR venography were performed.
Findings:
- Cerebral magnetic resonance imaging (MRI) confirmed the presence of cerebral venous thrombosis (CVT).
- MR venography further corroborated the diagnosis of CVT.
- No specific underlying cause for the thrombosis was identified in this patient.
Implications:
- This case highlights cerebral venous thrombosis (CVT) as a potential, albeit unusual, cause of stroke in adults with Down's syndrome (DS).
- Further research is warranted to explore the prevalence and risk factors of CVT in the DS population.
- Increased awareness among clinicians may improve early diagnosis and management of stroke in individuals with DS.
Abstract:
We report the first case of cerebral venous thrombosis (CVT) diagnosed in an adult with Down's syndrome (DS). A 25-year-old man with DS was admitted because of a generalized tonic-clonic seizure and prolonged postictal period. Cerebral magnetic resonance imaging (MRI) and MR venography revealed CVT. No particular cause of the thrombosis was identified. CVT may be an unusual cause of stroke in DS.