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Combretoxazolones: synthesis, cytotoxicity and antitumor activity
1College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|November 21, 2001
Abstract:
Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.