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Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
C Chamorro1, E Lobatón, M C Bonache
1Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006-Madrid, Spain.
Bioorganic & Medicinal Chemistry Letters
|November 21, 2001
Abstract:
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.