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The interaction of post-weaning housing conditions and prenatal drug effects on behaviour
Offspring of rats given oral doses of imipramine (5 mg/kg) from 14-2f gestation were reared, after weaning, in deprived or enriched environments. When tested in both a Henderson-type maze and a swimming maze no behavioural effects due to prenatal drug exposure were observed when the Ss were reared in a deprived environment. When the Ss were reared in an enriched environment the maze performance of those animals which had been exposed to imipramine or vitamin-A was significantly inferior to that of the control animals. The implications of these findings are discussed with respect to environmental interaction with prenatal drug effects on behavior.
Offspring of rats given oral doses of imipramine (5 mg/kg) from 14-2f gestation were reared, after weaning, in deprived or enriched environments. When tested in both a Henderson-type maze and a swimming maze no behavioural effects due to prenatal drug exposure were observed when the Ss were reared in a deprived environment. When the Ss were reared in an enriched environment the maze performance of those animals which had been exposed to imipramine or vitamin-A was significantly inferior to that of the control animals. The implications of these findings are discussed with respect to environmental interaction with prenatal drug effects on behavior.