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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Elevated interleukin-1beta in pericardial fluid of patients with ischemic heart disease

J Oyama1, H Shimokawa, S Morita

  • 1Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Coronary Artery Disease
|November 21, 2001
PubMed

Insights

Elevated interleukin-1 beta in pericardial fluid indicates greater ischemic heart disease extent. This cytokine may also directly contribute to coronary atherosclerosis progression.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biochemistry

Background:

  • Inflammatory cytokines are implicated in atherosclerosis and heart failure pathogenesis.
  • Interleukin-1 beta (IL-1β) treatment promotes coronary arteriosclerosis and impairs cardiac function.
  • Pericardial fluid cytokines may indicate coronary atherosclerosis severity and promote its progression.

Purpose of the Study:

  • To investigate the significance of cytokine concentrations in pericardial fluid of cardiovascular disease patients.
  • To assess the relationship between pericardial cytokines and specific heart conditions.

Main Methods:

  • Measured 10 major cytokines in pericardial fluid from 56 patients undergoing open heart surgery.
  • Patients were categorized into ischemic heart disease (IHD), valvular heart disease (VHD), and congenital heart disease (CHD) groups.

Main Results:

  • Pericardial IL-1β concentrations were significantly higher in the IHD group compared to VHD and CHD groups (P < 0.05).
  • No significant differences in other cytokine levels were observed among groups.
  • In the IHD group, elevated IL-1β was noted in patients with emergency operations or unstable angina.

Conclusions:

  • Pericardial IL-1β concentrations may serve as a marker for the extent of ischemic heart disease.
  • Elevated IL-1β in pericardial fluid could directly contribute to the progression of coronary atherosclerosis.
Abstract

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