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[Association of polymorphisms of apolipoprotein B gene with cholesterol gallstone disease]
1Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Surgery, Shanghai 200025.
Objective:
To investigate the association between the apolipoprotein B (apoB) gene polymorphic sites Ins/Del and Xbal, and cholesterol gallstone disease.
Methods:
The two polymorphic sites of apoB gene were examed in 101 cholesterol gallstone patients and 50 controls by polymerase chain reaction and restriction fragment length polymorphism methods.
Results:
For Xbal polymorphic site, the frequency of the rare allele X+ and the distribution of X+X- genotype were significantly higher in the patient group than in the control group (P < 0.05). For Ins/Del polymorphic site, no significant difference was found in allele frequency and genotype distribution between the patient group and the control group.
Conclusions:
Xba1 polymorphism of apoB gene may be associated with cholesterol gallstone disease. The association, however, is not present for Ins/De1 polymorphism of apoB gene with cholesterol gallstone disease.