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[The experimental research of transforming growth factor-beta 1 expression during fracture healing]
1Department of Orthopaedics, Third Hospital of Beijing Medical University, Beijing 100083.
Objective:
To observe the effect of TGF-beta 1 in the regulation of fracture healing.
Method:
The expression of transforming growth factor-beta 1 (TGF-beta 1) in different period of fracture healing was investigated by immunohistochemistry.
Results:
It was found that the expression of TGF-beta 1 changed in different period. The cells in the cambial layer of the periostlum showed low or negative signal in the immediate injury response period. The osteoblasts differentiated from the periosteum cells stained strongly in the intramembranous ossification period, and the differentiated chondrocytes stained most strongly in the chondrogenesis period. The hypertrophic chondrocytes showed negative signal and the osteoblasts stained strongly in the endochondral ossification period. These results suggested that the expression of TGF-beta 1 was closely related to the proliferation and differentiation state of repair cells.
Conclusion:
TGF-beta 1 is intimately involved in the control of fracture healing.