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[Conditions of development of a secondary immune response in guinea pig lymphoid cell cultures]

B V Pinegin

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |June 1, 1975
    PubMed

    On addition of a specific antigen to the cell culture of the lymph nodes of the immunized guinea pigs there was seen an intensification of the synthesis of the DNA and of the antibody formation. Both processes occurred more intensively in incubation of cells on a medium with an addition of rabbit antiserum to the guinea pig erythrocytes than on a medium with a normal homologous serum. It is supposed that the optimal conditions for the initiation of antibody formation in the lymphoid cells were created in case of a combined action of a specific antigen-inductor and a nonspecific stimulant intensifying the DNA synthesis.

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