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Updated: Oct 3, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
[In vitro testing for drug resistance and drug sensitivity in clinical oncology]
1Univerzitní onkologické centrum, oddĕlení klinické onkologie FN Brno, pracovistĕ Bohunice.
Abstract:
In vitro methods for testing chemosensitivity and chemoresistance can contribute considerably to more individual chemotherapy of a given patient. Different tests which reflect with a different reliability and specificity the probable ineffectiveness of chemotherapy can be divided into several categories: 1. Indirect tests associated with general biological activity of the tumour. 2. Tests based on the specific relationship to a certain cytostatic. 3. Examination of hormonal receptors. 4. Direct tests based on testing of the sensitivity or resistance of a tumour to different cytostatics in primocultures or stabilized cultures. The submitted review presents information on different methods.
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