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High early death rate in tuberculosis patients in Malawi
A D Harries1, N J Hargreaves, F Gausi
1National Tuberculosis Control Programme, Community Health Science Unit, Lilongwe, Malawi. adharries@malawi.net
Setting:
Thirty-eight district and mission hospitals in Malawi.
Objectives:
In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred.
Design:
A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books.
Results:
A total of 16,004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age.
Conclusions:
There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.