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Correlation between Bacillus subtilis scoC phenotype and gene expression determined using microarrays for

R Caldwell1, R Sapolsky, W Weyler

  • 1Genencor International, Palo Alto, California 94304, USA.

Journal of Bacteriology
|November 22, 2001
PubMed
Summary
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The Bacillus subtilis scoC gene regulates over 560 genes, impacting growth and development. This study reveals scoC

Area of Science:

  • Microbiology
  • Genomics
  • Molecular Biology

Background:

  • The complete Bacillus subtilis genome sequence enables large-scale studies.
  • The scoC gene's role in late-stage development and aprE expression is of interest.

Purpose of the Study:

  • To investigate the genome-wide effects of a scoC null mutant in Bacillus subtilis.
  • To understand the regulatory role of scoC in bacterial growth and developmental processes.

Main Methods:

  • Comparative transcriptome analysis of isogenic Bacillus subtilis strains.
  • Utilizing genome-wide DNA arrays to study gene expression patterns.

Main Results:

  • The scoC gene regulates at least 560 Bacillus subtilis genes, acting as both a repressor and activator.

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  • Expression changes were observed in genes related to metabolism, transport, motility, sporulation, and adaptation.
  • Regulatory genes, including sigma factors and sensor regulators, were also affected.

    • Conclusions:

    • ScoC plays a significant regulatory role in Bacillus subtilis, influencing diverse cellular processes.
    • Transcriptome alterations in the scoC mutant provide insights into its impact on bacterial phenotypes.