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Coagulation and inflammation.

T van der Poll1

  • 1Laboratory of Experimental Internal Medicine, and Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. T.vanderPoll@amc.uva.nl

Journal of Endotoxin Research
|November 22, 2001
PubMed
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Severe infection activates blood coagulation and inflammatory responses. This review covers how sepsis triggers procoagulant activity and how hemostatic regulators impact inflammation.

Area of Science:

  • Coagulation and Thrombosis
  • Inflammation and Immunology
  • Sepsis Pathophysiology

Background:

  • Severe infections, such as sepsis, trigger complex biological responses.
  • These responses involve both the coagulation system and inflammatory mediator cascades.
  • Understanding these interconnected pathways is crucial for managing severe infections.

Purpose of the Study:

  • To review the mechanisms driving the procoagulant response during sepsis.
  • To explore the dual role of hemostatic regulators in both coagulation and inflammation.
  • To synthesize current knowledge on the interplay between thrombosis and inflammation in sepsis.

Main Methods:

  • Literature review of current research on sepsis-induced coagulation.
  • Analysis of studies investigating inflammatory mediators in sepsis.

Related Experiment Videos

  • Synthesis of evidence on the bidirectional relationship between hemostasis and inflammation.

    • Main Results:

    • Sepsis activates the coagulation system through various inflammatory pathways.
    • Mediators traditionally regulating hemostasis also play roles in inflammatory processes.
    • The hemostatic system is intricately linked with systemic inflammation during severe infection.

    Conclusions:

    • The procoagulant response in sepsis is driven by multiple inflammatory mechanisms.
    • Hemostatic regulators possess functions beyond coagulation, influencing inflammatory pathways.
    • Targeting the interplay between coagulation and inflammation may offer therapeutic strategies for sepsis.