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[Observation on platelet aggregative ability in patients with malignant tumors of head and neck by electron
1ENT Department, First University Hospital, West China University of Medical Sciences, Chengdu 610041.
Objective:
To investigate the relationship between the platelet aggregative ability and malignant tumors of head and neck.
Method:
Platelet aggregative ability was detected by electron microscopy (EM) in 37 patients with malignant tumors of head and neck(Group C), 10 patients with non-neoplastic diseases(Group A) and 10 patients with benign tumors of head and neck(Group B) as the control group, with the ratio of aggregative type platelets as the index. Twenty-five of 37 patients with malignant tumors except 8 cases of nasopharyngeal carcinoma were included in the follow-up study 4-6 months after operations.
Results:
1. The mean ratio of aggregative type platelets in patients from Group C was significantly higher that that of Group A or Group B patients (P < 0.05); 2. In Group C, the mean ratio of aggregative type platelets increased significantly with the development of clinical staging(P < 0.05); 3. In follow-up study, the mean ratio of aggregative type platelets of 17 patients without metastasis and recurrence was significantly lower than that before-operation, while the results of 8 patients with metastasis or recurrence was totally opposite.
Conclusions:
1. The aggregative ability of platelets increased in patients with malignant tumors of head and neck; 2. The ratio of aggregative type platelets detected by EM has an important potential value in judging the development, therapeutic effects and prognosis of the malignant tumors of head and neck.
