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[A specific property of microvasomotion in the guinea pig cochlea]
Objective:
To investigate specific property of vasomotion in cochlear microvessels and its response to the endothelium-derived relaxation factor (EDRF).
Methods:
The dynamic changes of cochlea microvessels were observed using intravital microscopy and measured by the microcirculatory image processing system. The frequency and amplitude of vasomotion were analyzed with fast Fourier transform (FFT) according to the diameter changes.
Results:
The vasomotion of cochlear arteriole with a small amplitude existed in normal condition. The diameter changed from (10.41 +/- 3.03) microns to (12.29 +/- 1.9) microns with a mean value of (11.2 +/- 2.7) microns. The specific property of vasomotion was characterized by a frequency (0.021 +/- 0.002) Hz and amplitude of (0.37 +/- 0.11) micron. The contraction index was determined as 0.42 +/- 0.17. The vasomotion was significantly enhanced after the administration of EDRF.
Conclusion:
The vasomotion existed in the cochlea and EDRF can increase the cochlear blood flow by improving the vasomotion.