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Updated: Sep 26, 2026
Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
Published on: September 17, 2015
Comparative effects of losartan and captopril on ventricular remodeling and function after myocardial infarction in
1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032.
Objective:
To determine the effects of losartan and captopril treatment on ventricular remodeling and function after myocardial infarction in rats.
Methods:
Thirty-two rats with MI induced by coronary ligation after seven days were divided into four groups randomly and treated with captopril(2 g.liter-1, group A), losartan(10 mg.kg-1.d-1, group B), losartan(30 mg.kg-1.d-1, group C) and placebo (no drug, group D) for six weeks, respectively. Sham-operated rats(group E) served as controls. Echocardiography was performed at 1 and 7 weeks after MI, respectively.
Results:
Compared with the results before treatment, both LV end-diastolic internal diameter and volume decreased significantly and the thickened posterior wall was reversed in group A, B and C; the peak early filling velocity decreased whereas the peak velocity was increased in these three groups. There are no significant difference among the three treated groups. However, LV end-diastolic internal diameter and the E/A were still increased, whereas the thickness of anterior wall and the peak velocity of LV outflow were decreased in group A, B, and C after treatment comparing with group E.
Conclusion:
Both angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist can prevent the ventricular remodeling and improve the ventricular function.
