Related Experiment Video

Updated: Oct 3, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

[The relationship of variability of blood pressure with cardiac structure and functions in hypertension]

H He1, Y Sun, B Zhou

  • 1Department of Cardiology, Affiliated Sir Run Run Shaw Hospital in Medical College, Zhejiang University, Hangzhou 310016, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|November 23, 2001
PubMed

Insights

Essential hypertension damages diastolic cardiac function and is linked to left ventricular hypertrophy. Blood pressure variability and vascular overload significantly impact cardiac changes, more so than age.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Cardiac Physiology

Context:

  • Essential hypertension is a prevalent cardiovascular condition.
  • Left ventricular hypertrophy (LVH) is a common complication.
  • Understanding the interplay between blood pressure variability and cardiac remodeling is crucial.

Purpose:

  • To investigate the relationship between blood pressure variability and cardiac structure/function in essential hypertension.
  • To compare cardiac parameters in hypertensive patients with and without LVH.

Summary:

  • A study of 110 essential hypertension patients revealed significant differences in left ventricular mass, dimensions, and diastolic function (E/A ratio) between groups with and without LVH.
  • Elevated systolic blood pressure load, 24-hour SBP, nocturnal SBP reduction rate, and blood pressure variability (systolic and mean arterial pressure) were significantly different between the groups.
  • LVH in essential hypertension is associated with vascular overload, increased blood pressure variability, and nocturnal SBP reduction, with a weaker link to hypertensive age.

Impact:

  • Findings highlight that diastolic cardiac function is impaired early in essential hypertension.
  • Identifies key hemodynamic factors contributing to LVH, offering targets for intervention.
  • Suggests that blood pressure variability and vascular overload are more significant drivers of LVH than previously recognized.
Abstract

More Related Videos

Assessing Murine Resistance Artery Function Using Pressure Myography07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Blood Pressure01:30

Blood Pressure

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...