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Nocturnal blood pressure dip in CADASIL
Y Manabe1, T Murakami, K Iwatsuki
1Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan. manabe@cc.okayama-u.ac.jp
Journal of the Neurological Sciences
|November 24, 2001
Summary
A reduced nocturnal blood pressure dip is linked to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). This finding suggests a potential association with disease progression and white matter lesions in CADASIL patients.
Area of Science:
- Neurology
- Cardiology
- Genetics
Background:
- Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetic small vessel disease.
- The role of nocturnal blood pressure patterns in CADASIL pathogenesis remains unclear.
Purpose of the Study:
- To investigate the association between nocturnal blood pressure dipping and CADASIL.
- To explore the correlation between blood pressure circadian rhythms and CADASIL severity.
Main Methods:
- Ambulatory blood pressure monitoring was used in 5 CADASIL patients and 10 controls.
- Patients were categorized into dippers, non-dippers, and inverted dippers based on nocturnal mean arterial blood pressure (MABP) fall.
- Circadian blood pressure patterns were analyzed to assess nocturnal MABP reduction.
Main Results:
- CADASIL patients exhibited significantly lower nighttime MABP fall compared to controls (P<0.01).
- Three CADASIL patients were classified as non-dippers, and two as inverted dippers.
- A reduced nocturnal blood pressure fall was observed in the patient cohort.
Conclusions:
- Lower nocturnal blood pressure fall may be associated with the incidence or progression of deep white matter lesions in CADASIL.
- Nocturnal hypotension could be a contributing factor to CADASIL pathology.
- Further research is warranted to elucidate the precise relationship between blood pressure variability and CADASIL outcomes.