Nocturnal blood pressure dip in CADASIL

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Published on: July 29, 2016

Y Manabe1, T Murakami, K Iwatsuki

  • 1Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan. manabe@cc.okayama-u.ac.jp

Journal of the Neurological Sciences
|November 24, 2001
PubMed

Insights

A reduced nocturnal blood pressure dip is linked to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). This finding suggests a potential association with disease progression and white matter lesions in CADASIL patients.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetic small vessel disease.
  • The role of nocturnal blood pressure patterns in CADASIL pathogenesis remains unclear.

Purpose of the Study:

  • To investigate the association between nocturnal blood pressure dipping and CADASIL.
  • To explore the correlation between blood pressure circadian rhythms and CADASIL severity.

Main Methods:

  • Ambulatory blood pressure monitoring was used in 5 CADASIL patients and 10 controls.
  • Patients were categorized into dippers, non-dippers, and inverted dippers based on nocturnal mean arterial blood pressure (MABP) fall.
  • Circadian blood pressure patterns were analyzed to assess nocturnal MABP reduction.

Main Results:

  • CADASIL patients exhibited significantly lower nighttime MABP fall compared to controls (P<0.01).
  • Three CADASIL patients were classified as non-dippers, and two as inverted dippers.
  • A reduced nocturnal blood pressure fall was observed in the patient cohort.

Conclusions:

  • Lower nocturnal blood pressure fall may be associated with the incidence or progression of deep white matter lesions in CADASIL.
  • Nocturnal hypotension could be a contributing factor to CADASIL pathology.
  • Further research is warranted to elucidate the precise relationship between blood pressure variability and CADASIL outcomes.

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