Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA repair: how Ku makes ends meet.

A J Doherty1, S P Jackson

  • 1Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK. ajd42@cam.ac.uk

Current Biology : CB
|November 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic determinants of micronucleus formation in vivo.

Nature·2024
Same author

Eating well, living well and weight management: A co-produced semi-qualitative study of barriers and facilitators experienced by adults with intellectual disabilities.

Journal of intellectual disabilities : JOID·2018
Same author

A non-canonical mismatch repair pathway in prokaryotes.

Nature communications·2017
Same author

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Survivability of Escherichia coli O157:H7 in mechanically tenderized beef steaks subjected to lactic acid application and cooking under simulated industry conditions.

Journal of food protection·2013
Same author

Differentiating haemostasis from thrombosis for therapeutic benefit.

Thrombosis and haemostasis·2013
Same journal

Proprioceptive cortical neurons implement optimal state estimation.

Current biology : CB·2026
Same journal

Coumarins link iron deficiency to TOR inhibition in plants.

Current biology : CB·2026
Same journal

Space-based monitoring of penguin diet links sea ice, food webs, and population change.

Current biology : CB·2026
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
See all related articles

The Ku heterodimer's crystal structure reveals its DNA repair mechanism. Understanding this protein

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • The Ku heterodimer is crucial for DNA double-strand break repair.
  • Its precise mechanism has been a subject of extensive research.

Purpose of the Study:

  • To elucidate the DNA repair mechanism of the Ku heterodimer.
  • To analyze the structural basis of Ku heterodimer function in DNA repair.

Main Methods:

  • X-ray crystallography was used to determine the crystal structure of the Ku heterodimer.
  • Structural analysis was performed on both DNA-bound and unbound forms of the protein.

Main Results:

  • The crystal structure provides new insights into the Ku heterodimer's interaction with DNA.

Related Experiment Videos

  • The structural data illuminates the protein's role in initiating DNA double-strand break repair.

    • Conclusions:

    • The determined structures offer a detailed understanding of the Ku heterodimer's function in DNA repair.
    • This structural information is vital for future research on DNA repair pathways.