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Membrane transport: ubiquitylation in endosomal sorting
S Dupré1, C Volland, R Haguenauer-Tsapis
1Institut Jacques Monod, Universités Paris VI and Paris VII, 2 place Jussieu, 75251 PARIS Cedex 05, France.
Current Biology : CB
|November 24, 2001
Abstract:
In yeast, membrane proteins from the biosynthetic and endocytic pathways must be ubiquitylated for sorting to inward-budding vesicles in late endosomes, which give rise to multivesicular bodies. A conserved protein complex containing the yeast Vps23p or its mammalian counterpart Tsg101 may act as the ubiquitin receptor.