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Related Experiment Videos

Red wine decreases cyclosporine bioavailability.

S M Tsunoda1, R Z Harris, U Christians

  • 1School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA. stsunoda@u.washington.edu

Clinical Pharmacology and Therapeutics
|November 24, 2001
PubMed
Summary

Drinking red wine with cyclosporine significantly reduces drug exposure. This interaction may impact the effectiveness of cyclosporine, a critical medication, highlighting the need for caution.

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Area of Science:

  • Pharmacology
  • Drug Interactions
  • Clinical Pharmacology

Background:

  • Common substances like grapefruit juice interact with therapeutic drugs.
  • Mechanisms involve cytochrome P4503A4 (CYP3A4) and P-glycoprotein.
  • Red wine may interact with CYP3A4 substrates like cyclosporine.

Purpose of the Study:

  • To investigate the effect of red wine on cyclosporine pharmacokinetics.
  • To determine if red wine alters cyclosporine absorption or metabolism.

Main Methods:

  • Randomized, 2-way crossover study in 12 healthy individuals.
  • Administered oral cyclosporine with water versus red wine.
  • Analyzed whole blood cyclosporine and metabolite levels.

Main Results:

Related Experiment Videos

  • Red wine increased cyclosporine oral clearance by 50%.
  • Area under the curve (AUC) and peak concentration (Cmax) significantly decreased.
  • Half-life remained unchanged, suggesting reduced absorption.

Conclusions:

  • Red wine significantly decreases cyclosporine exposure.
  • Caution is advised when consuming red wine with cyclosporine.
  • Cyclosporine's narrow therapeutic index necessitates careful consideration of co-ingested substances.