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TT dinucleotides containing an isoxazoline moiety: synthesis and binding affinity study
1Department of Chemistry, Center for Integrated Molecular Systems, Pohang University of Science and Technology, Pohang, Korea.
Nucleosides, Nucleotides & Nucleic Acids
|November 27, 2001
Abstract:
We have prepared four diastereomers of TT dinucleotides containing an isoxazoline moiety and four dodecanucleotides incorporating these TT dinucleotides in the middle of the DNA sequence. We also have determined the melting temperatures of these modified oligonucleotides (Tm values) by measuring change in UV absorbance.