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Conformational rigidity introduced by 2',5'-phosphodiester links in DNA
1Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
Nucleosides, Nucleotides & Nucleic Acids
|November 27, 2001
Abstract:
Conformational properties of 2',5'-linked 3'-deoxyribonucleotides have been compared with their natural isomer using CD spectroscopy. It is inferred from the salt induced titration curves that the 2',5'-linked-3'deoxyribonucleotides have rigid phosphodiester backbone.