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Synthesis of 5-methylamino-2'-deoxyuridine derivatives
B Catalanotti1, A Galeone, L Mayol
1Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
Nucleosides, Nucleotides & Nucleic Acids
|November 27, 2001
Abstract:
Reductive amination of 3',5'-O-(tetraisopropyldisilyloxane-1,3-diyl)-2'-deoxy-5-formyluridine with several aliphatic and aromatic amines, in various solvents, is described. In the case of aliphatic amines, the expected C-5 substituted methylamino pyrimidine nucleosides are formed along with by-products deriving from opening of the pyrimidine ring. Relative amounts of the by-products depend upon the polarity of the solvent employed.