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Updated: Aug 9, 2026
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 24, 2014
Lack of effect of gender on retinopathy in the mouse
R D Higgins1, Y Yan, M Tadesse
1Department of Paediatrics, Georgetown University Children's Medical Center, Washington, DC 20007, USA. higginrd@georgetown.edu
Background:
The reported effect of gender on retinopathy of prematurity has been controversial. The goal of this study was to determine the effect of gender on oxygen-induced retinopathy in a mouse model.
Methods:
Oxygen-induced retinopathy was produced in C57BL6 mice by exposure to 75% oxygen from postnatal day (P) 7 for 5 days. Animals were returned to room air on P12 and killed on P17-21. Gender was determined by inspection. Retinopathy was evaluated by a retinopathy scoring system and by quantifcation of extraretinal neovascular nuclei on retinal sections.
Results:
Both males and females developed similar degrees of retinopathy. Males had a median total retinopathy score of 9 (25th, 75th quartile: 8, 11) and females had score of 9 (25th, 75th quartile: 7, 10). Retinal subscores of blood vessel growth, blood vessel tufts, extraretinal neovascularzation, haemorrhage and blood vessel tortuosity were similar in both groups. Males and females had a similar number of neovascular nuclei on retinal sections.
Conclusions:
Gender does not alter the development of oxygen-induced retinopathy in the C57BL6 mouse.
