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Related Experiment Videos

Microsatellite instability in malignant melanomas.

M M Kroiss1, T M Vogt, J Schlegel

  • 1Department of Dermatology, University of Regensburg, Germany. wilhelm.stolz@klinik.uni-regensburg.de

Acta Dermato-Venereologica
|November 27, 2001
PubMed
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Microsatellite instability (MSI) occurs in malignant melanomas, increasing with tumour progression. This DNA repair defect is absent in benign naevi but found in a significant subset of melanomas.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Microsatellite instability (MSI) results from DNA mismatch repair deficiency, leading to a mutator phenotype.
  • Contradictory findings exist regarding the frequency and significance of MSI in malignant melanomas.

Purpose of the Study:

  • To determine the onset and frequency of MSI during melanocytic tumour progression.
  • To investigate MSI in benign melanocytic naevi, primary melanomas, and melanoma metastases.

Main Methods:

  • Analysis of 7 microsatellite loci.
  • Examination of 9 melanocytic naevi, 25 primary malignant melanomas, and 8 melanoma metastases.

Main Results:

  • No MSI was detected in benign melanocytic naevi.

Related Experiment Videos

  • MSI frequency increased with melanoma thickness and stage, observed in 8% of thin melanomas, 12% of intermediate melanomas, and over 25% of metastases.
  • A pattern of increasing MSI frequency correlated with tumour progression was identified.

    • Conclusions:

    • MSI is present in a considerable subset of malignant melanomas.
    • The frequency of MSI increases with the progression of melanocytic tumours, suggesting its role in melanoma development.